@article{Qassem_2021, title={EFFECT OF AQUEOUS CRUDE EXTRACT OF ALOE VACILLANS LEAVES ON INDUCED HEPATIC DAMAGE IN MALE RABBITS}, volume={2}, url={https://ejua.net/index.php/EJUA-BA/article/view/83}, DOI={10.47372/ejua-ba.2021.1.83}, abstractNote={<p style="text-align: justify;">This study was designed to evaluate the effects of aqueous extract of <em>Aloe vacillans</em> leaves juice on carbon tetrachloride (CCl<sub>4</sub>)- induced hepatotoxicity in rabbits. Hepatotoxicity was induced in rabbits by intraperitoneal injection of (CCl<sub>4</sub>) at dose l ml/kg on day 7 and 8.<br>The aqueous crude extract of <em>Aloe vacillans</em> leaves was administrated at dose 100 mg,300 mg and 500 mg/kg of body weight pass orally (p.o) daily for 8 days. The hepatotoxicity and its prevention were assessed by serum parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin (Bil) and total protein (T.P). <br>In CCl<sub>4</sub> treated rabbits, a significant, increasing the ALT, AST, bilirubin and decreasing the Total protein levels were shown (p<0.05), due to liver damage, when compared with the normal group.<br>Treatment with the aqueous extract of <em>Aloe vacillans</em> could significantly decrease the (ALT), (ALT) and bilirubin, increased T.P in serum at p< 0.05 when compared with CCl<sub>4</sub> –treated group <br>The data concluded that oral administration of aqueous extract of the leaves of <em>Aloe vacillans</em> significantly decreases the intensity of hepatic damage induced by CCl<sub>4</sub> in rabbits.</p>}, number={1}, journal={Electronic Journal of University of Aden for Basic and Applied Sciences}, author={Qassem, Mohammed Ali}, year={2021}, month={Mar.}, pages={01–06} }