ASSOCIATION OF AGE AND DIABETES DURATION WITH ESTIMATED GLOMERULAR FILTRATION RATE IN PATIENTS WITH DIABETES MELLITUS ATTENDING AL-DOFIAH MARTYR HOSPITAL-BEIHAN, SHABWAH, YEMEN

Abstract

Chronic kidney disease (CKD) is a common complication of Diabetes Mellitus (DM) and limits treatment options in DM. Estimated glomerular filtration rate (eGFR) is a crucial test for renal assessment. Significant association was found between risk factors and lower eGFR. Ageing is a natural and inevitable biological process that affects all organs. In Yemen, the association between rate of kidney function decline and age or/and duration of diabees has not been well investigated. The current study aimed to determine the association between eGFR and age or/with duration of DM. 177 individuals with DM were studied for the analysis of the association between eGFR rate with age and diabetes duration during the period of February 2022 to February 2023. Results showed high significant differences found in age groups based on eGFR. However, significant difference between the values of eGFR in age groups 25-34, 45-54 and 55-64. Except in the 7 age group, the eGFR of individuals in age groups tended to decreased. In the whole section, prevalence of CKD (high and very high risk) was 16.9% and increased progressively with age. The CKD associated with each 5 year increase in diabetes duration. Of these patients, 11.3% had an eGFR of 15-29 and < 15mL/min/1.73m², and 5.6% had an eGFR of 30-44 mL/min/1.73m². In the 4 category (15 years), 4% of study subjects were treated with stage 5 of eGFR (very high risk). The shape of the association between age with diabetes duration and risk of CKD was linear. The results of our study and the other kinds of literature indicate that the important of estimated glomerular filtration rate (eGFR) according to age, diabetes duration and degree of renal dysfunction. In conclusion: These results emphasize the importance of assessment of eGFR for CKD risk prediction in diabetes patients. Our findings suggested that early diagnosis and treatment is important for these patients. So, the observation that could guide preventative efforts of efficient glucose-lowering and renal protective strategies are needed in persons with DM.