THE ROLE OF NEUTROPHILS TO LYMPHOCYTES RATIO AS PREDICTIVE BIOMARKER IN ACUTE MYOCARDIAL INFARCTION PATIENTS AT AL-GAMHURIA MODERN GENERAL HOSPITAL – ADEN-YEMEN

Abstract

Inflammation plays a fundamental role in the development of atherosclerosis and in the pathogenesis of acute myocardial infarction (AMI). Neutrophils to lymphocytes ratio (NLR) was recognized as important inflammatory marker in predicting the severity and prognosis of AMI. The aim of this study is to determine the role of NLR as predictive biomarker in AMI patients at Al-Gamhuria Modern General Hospital. This study was considered a descriptive cross-sectional study, which was conducted in Al-Gamhuria Modern General Hospital from March through August 2022. The study includes 124 patients diagnosed as AMI and classified into two groups: 70 patients with low NLR and 54 patients with high NLR. Out of 124 patients, 56.5% of patients had low NLR and 43.5% had high NLR. Patients with high NLR were older (62.31 ± 7.30 vs. 57.80 ± 5.17 years), had higher prevalence of D.M., hyperlipidemia, more smokers and Khat chewers compared to patients with low NLR. High NLR group had more elevated CK-MB and Troponin T, more reduced ejection fraction (EF) and fractional shortening (FS) compared to low NLR group (P < 0.001). High NLR group also had poorer Killip class (P < 0.001), and were more prone to death inside the hospital compared to low NLR group (11.1% vs. 1.4%), (P= 0.042). As conclusion, NLR is a strong predictor of myocardial damage, myocardial dysfunction as well as in-hospital mortality in patients with AMI. NLR as an inflammatory marker can also predict the consequences on the heart post-MI.